The advantage of a federal system is that it provides a means of imposing at least a little sanity.
Texas (as just one example) is already on the road to become a libertarian theocracy. Imagine how it will look if it goes its own way. The Texas Emirate will be impose even crazier Sharia law than it already does.
So? Let them and get out of there if you don't like it.
Easier said than done if you're poor and stuck.
Alternatively, the notion of Cascadia spreading its environmental hopes to everyone else would also die.
Breaking the country apart is just another word for giving up and letting the far right nutbags win.
You'd end up with a Gilead in that mix, for sure. Or something a lot like it. Do you really want that for the people who live in that territory?